Regulatory CD4+CD25+ T Cells Restrict Memory CD8+ T Cell Responses

Regulatory CD4+CD25+ T Cells Restrict Memory CD8+ T Cell Responses

CD4+ T cell help is important for the generation of CD8+ T cell responses. We used depleting anti-CD4 mAb to analyze the role of CD4+ T cells for memory CD8+ T cell responses after secondary infection of mice with the intracellular bacterium Listeria monocytogenes, or after boost immunization by specific peptide or DNA vaccination. Surprisingly, anti-CD4 mAb treatment during secondary CD8+ T ce...

Memory CD4 T cells enhance primary CD8 T-cell responses.

CD4 T-cell help is required for optimal memory CD8 T-cell responses. We have found that engaging preexisting CD4 Th1, but not Th2, memory cells at the time of CD8 T-cell priming results in increased CD8 effector responses to both bacterial and viral pathogens. The enhanced responses are characterized by increased numbers of cytokine-producing, antigen-specific cells. These findings suggest that...

Regulatory T cells can prevent memory CD8+ T-cell-mediated rejection following polymorphonuclear cell depletion

Accumulating evidence suggests that alloreactive memory T cells (Tm) may form a barrier to tolerance induction in large animals and humans due in part to a resistance to suppression by Treg. However, why Tm are resistant to regulation and how the Tm response to an allograft differs from that of naïve T cells, which are amenable to suppression by Treg, remains unknown. Here, we show that acceler...

Human Cord Blood CD4CD25 Regulatory T Cells Suppress Prenatally Acquired T Cell Responses to Plasmodium falciparum Antigens

CD4CD25 Regulatory T Cells Preventing Detrimental Autoimmune Reactions

Objective: Autoimmune diseases will occur when the immune response inflicts damage to tissues in the body. Attempts to overcome this disease have a lot to do but they have not yielded satisfying results. In this study, the function of CD4CD25 regulatory T cells was evaluated for therapeutic potential to prevent the development of autoreactive T